BRI1 EMS SUPPRESSOR1 (BES1) family members are crucial downstream regulators that positively mediate brassinosteroid signaling, playing vital roles in the regulation of plant stress responses and anther development in Arabidopsis.Importantly, the expression profiles of wheat (Triticum aestivum L.) BES1 genes have not been analyzed comprehensively a
Models of good practice to enhance infectious disease care cascades among people who inject drugs: a qualitative study of interventions implemented in European settings
Abstract Background People who Algorithm for scenario benefit route planning based on user’s requests inject drugs (PWID) in Europe are at an increased risk of HIV/AIDS, chronic viral hepatitis B (HBV) and C (HCV), and tuberculosis (TB).We aimed to complement the evidence base on interventions optimising their care cascade with evidence from mode
Design and Development of a Deep Learning-Based Model for Anomaly Detection in IoT Networks
The growing development of IoT (Internet of Things) devices creates a large attack surface for cybercriminals to conduct potentially more destructive cyberattacks; as a result, the security industry has seen an exponential increase in cyber-attacks.Many of these attacks have effectively accomplished their malicious goals because intruders conduct c
Comparative analysis of image enhancement techniques for braintumor segmentation: contrast, histogram, and hybrid approaches
This study systematically investigates the impact of image enhancement techniques on Convolutional Neural Network (CNN)-based Brain Tumor Segmentation, focusing on Histogram Equalization (HE), Contrast Limited Adaptive Histogram Equalization (CLAHE), and their hybrid variations.Employing the U-Net architecture on a dataset of 3064 Brain MRI images,
Intrastriatal Administration of AAV5-miHTT in Non-Human Primates and Rats Is Well Tolerated and Results in miHTT Transgene Expression in Key Areas of Huntington Disease Pathology
Huntington disease (HD) is a fatal, neurodegenerative genetic disorder with aggregation of mutant Huntingtin protein (mutHTT) in the brain as a key pathological mechanism.There are currently no disease modifying therapies for HD; however, HTT-lowering therapies hold promise.Recombinant adeno-associated virus serotype 5 expressing a microRNA that ta